Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 2/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7374457 | 0.84 | TACR1 (0.51) | ALDH1A1MEN1KMT2ASMN1; SMN2TACR1 | |
| SCHEMBL7374560 | 0.83 | KMT2A (0.58) | ALDH1A1MEN1KMT2ASMN1; SMN2LTB4R2 | |
| SCHEMBL14679109 | 0.78 | CA12 (0.51) | ALDH1A1KMT2ASMN1; SMN2LMNACA12 | |
| SCHEMBL28660780 | 0.78 | LMNA (0.49) | ALDH1A1MEN1KMT2ASMN1; SMN2LTB4R2 | |
| SCHEMBL3230316 | 0.77 | TSHR (0.65) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL29500171 | 0.77 | TSHR (0.65) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL14134245 | 0.76 | KEAP1 (0.54) | ALDH1A1MEN1KMT2ASMN1; SMN2LTB4R2 | |
| SCHEMBL7102292 | 0.74 | KMT2A (0.57) | ALDH1A1MEN1KMT2ASMN1; SMN2LTB4R2 | |
| SCHEMBL8785261 | 0.73 | LMNA (0.46) | MEN1KMT2ALMNACA12CA1 | |
| SCHEMBL9182128 | 0.73 | KMT2A (0.45) | ALDH1A1MEN1KMT2ASMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6060462-A | Electrophilic peptide analogs as inhibitors of trypsin-like enzymes | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-05-09 | — | — | US | disclosed |
| EP-0724446-A4 | ELECTROPHILIC PEPTIDE ANALOGS AS INHIBITORS OF TRYPSIN-LIKE ENZYMES | DU PONT MERCK PHARMA (US) | 1998-01-07 | — | — | EP | disclosed |
| EP-0724446-A1 | ELECTROPHILIC PEPTIDE ANALOGS AS INHIBITORS OF TRYPSIN-LIKE ENZYMES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995009634-A1 | ELECTROPHILIC PEPTIDE ANALOGS AS INHIBITORS OF TRYPSIN-LIKE ENZYMES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-04-13 | — | — | WO | disclosed |