Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7850510 | 0.84 | KMT2A (0.39) | KMT2AMEN1CA12CA1CA2 | |
| SCHEMBL7374457 | 0.80 | TACR1 (0.51) | KMT2AMEN1CA12CA1CA2 | |
| SCHEMBL8785404 | 0.76 | KMT2A (0.47) | KMT2AALDH1A1SMN1; SMN2NPC1GAA | |
| SCHEMBL13468195 | 0.75 | KMT2A (0.58) | KMT2AMEN1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL8785261 | 0.74 | LMNA (0.46) | KMT2AMEN1CA12CA1CA2 | |
| SCHEMBL7374463 | 0.73 | ALDH1A1 (0.50) | KMT2AMEN1CA12CA1CA2 | |
| SCHEMBL7849671 | 0.72 | ALDH1A1 (0.52) | KMT2AMEN1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL12499605 | 0.72 | KMT2A (0.43) | KMT2AMEN1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL7375054 | 0.72 | PDE3B (0.49) | KMT2AMEN1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL9401553 | 0.72 | LMNA (0.43) | CA12CA1CA2CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0481383-B1 | Heterocyclic amine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5300646-A | Intermediates for acylcoenzyme A:cholesterol acyltransferase inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-04-05 | — | — | US | disclosed |
| US-5198462-A | Acyl Coenzyme A:Cholesterol Transferase Inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-03-30 | — | — | US | disclosed |
| EP-0481383-A1 | Heterocyclic amine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1992-04-22 | — | — | EP | disclosed |