Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 2/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.44 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | KRAS | P01116 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.39 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7372110 | 0.82 | PRKD3 (0.44) | CDC7CDK2IMPDH2MAPK1MEN1 | |
| SCHEMBL27993072 | 0.81 | PRKD3 (0.42) | CDC7CDK2IMPDH2MAPK1MEN1 | |
| SCHEMBL16720154 | 0.75 | IMPDH2 (0.34) | IMPDH2MAPK1MEN1CYP19A1TBXAS1 | |
| SCHEMBL6664883 | 0.73 | CDC7 (0.49) | TGFBR1TGFBR2CDC7CDK2HSP90AA1 | |
| SCHEMBL3400595 | 0.71 | IMPDH2 (0.43) | TDO2TGFBR1IMPDH2MAPK1HSD17B10 | |
| SCHEMBL1150401 | 0.71 | FGFR1 (0.53) | TGFBR1TGFBR2CDC7CDK2CYP19A1 | |
| SCHEMBL9464864 | 0.70 | MEN1 (0.54) | IMPDH2MAPK1HSD17B10MEN1CYP19A1 | |
| SCHEMBL4860243 | 0.69 | HTR6 (0.36) | HASPINCCNT1PIM1CDK9 | |
| SCHEMBL7371067 | 0.69 | CCNT1 (0.55) | TDO2CDC7CDK2IMPDH2CYP19A1 | |
| SCHEMBL6466793 | 0.68 | ATM (0.34) | IMPDH2MAPK1MEN1CYP19A1TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743942-A1 | 5-HETEROARYLINDOLE DERIVATIVES AS BENZODIAZEPINE RECEPTOR SITE AGONISTS AND ANTAGONISTS | PFIZER INC. (US) | 1996-11-27 | — | — | EP | disclosed |
| WO-1995021836-A1 | 5-HETEROARYLINDOLE DERIVATIVES AS BENZODIAZEPINE RECEPTOR SITE AGONISTS AND ANTAGONISTS | PFIZER INC. (US) | 1995-08-17 | — | — | WO | disclosed |