Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | TCF4 | P15884 | 2/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | ATIC | P31939 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7049185 | 0.87 | F2 (0.42) | PLGPLAUTCF4CTNNB1F2 | |
| SCHEMBL7379442 | 0.86 | PLG (0.54) | PLGPLAUKMT2AALDH1A1MEN1 | |
| SCHEMBL7369185 | 0.80 | PLAU (0.36) | PLAUF2TMPRSS6 | |
| SCHEMBL7374054 | 0.79 | PLAU (0.38) | PLAUF2ALDH1A1TMPRSS6 | |
| SCHEMBL7375772 | 0.79 | PLAU (0.38) | PLGPLAUF2LMNAGAA | |
| SCHEMBL7368832 | 0.76 | F2 (0.40) | PLGF2ALDH1A1TMPRSS6MAPT | |
| SCHEMBL6436937 | 0.76 | PLG (0.53) | PLGPLAUTCF4CTNNB1F2 | |
| SCHEMBL7372723 | 0.76 | MMP2 (0.35) | KMT2AMEN1 | |
| SCHEMBL7369764 | 0.74 | CYP2C9 (0.52) | SMN1; SMN2LMNAGAAKMT2AALDH1A1 | |
| SCHEMBL7378754 | 0.74 | PLAU (0.41) | PLAUSMN1; SMN2LMNAGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |