Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 5/20 | 0.38 |
| ▸ | PLG | P00747 | 3/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GALK1 | P51570 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7374993 | 0.89 | PLAU (0.42) | PLAUPLGPLATALDH1A1KDM4E | |
| SCHEMBL7366260 | 0.87 | PLAU (0.39) | PLAUPLGPLATALDH1A1KDM4E | |
| SCHEMBL7372723 | 0.86 | MMP2 (0.35) | L3MBTL1 | |
| SCHEMBL7368832 | 0.85 | F2 (0.40) | PLGALDH1A1MAPTPOLBF2 | |
| Hydrochloric Acid SCHEMBL7376139 | 0.84 | PLAU (0.51) | PLAUPLGPLATALDH1A1GAA | |
| SCHEMBL7369185 | 0.83 | PLAU (0.36) | PLAUF2 | |
| SCHEMBL7374054 | 0.81 | PLAU (0.38) | PLAUALDH1A1F2 | |
| SCHEMBL7375012 | 0.79 | PLG (0.41) | PLAUPLGALDH1A1GAALMNA | |
| Hydrochloric Acid SCHEMBL7588559 | 0.79 | PLG (0.52) | PLAUPLGPLAT | |
| SCHEMBL7370338 | 0.77 | PLAU (0.34) | PLAUPLGPLATALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |