Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 8/20 | 0.40 |
| ▸ | TMPRSS6 | Q8IU80 | 8/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 5/20 | 0.36 |
| ▸ | MMP9 | P14780 | 3/20 | 0.36 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | HPN | P05981 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363440 | 0.88 | POLB (0.40) | F2POLBCTSLCTSSMMP2 | |
| SCHEMBL7372723 | 0.88 | MMP2 (0.35) | MMP2MMP9 | |
| SCHEMBL7375772 | 0.85 | PLAU (0.38) | F2POLBPLGALDH1A1MAPT | |
| SCHEMBL7369185 | 0.80 | PLAU (0.36) | F2TMPRSS6 | |
| SCHEMBL7363430 | 0.79 | PLAU (0.42) | POLBALDH1A1MAPT | |
| SCHEMBL7374054 | 0.79 | PLAU (0.38) | F2TMPRSS6ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7369278 | 0.77 | PLAU (0.36) | POLBMMP2MMP9ADAMTS4PLG | |
| SCHEMBL7378754 | 0.77 | PLAU (0.41) | ALDH1A1MAPT | |
| SCHEMBL6432944 | 0.77 | F2 (0.42) | F2TMPRSS6POLBCTSLCTSS | |
| SCHEMBL7368871 | 0.76 | MMP9 (0.49) | MMP2MMP9ADAMTS4PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |