Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7235017 | 0.91 | NPC1 (0.49) | ALDH1A1SMN1; SMN2KDM4EPOLBMAPT | |
| SCHEMBL7372857 | 0.88 | MAPT (0.41) | ALDH1A1SMN1; SMN2KDM4EPOLBMAPT | |
| SCHEMBL7233460 | 0.77 | SMN1; SMN2 (0.52) | ALDH1A1SMN1; SMN2KDM4EPOLBMAPT | |
| SCHEMBL28851913 | 0.75 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2KDM4EPOLBMAPT | |
| SCHEMBL9571764 | 0.74 | RAB9A (0.68) | ALDH1A1SMN1; SMN2KDM4EMAPTNPC1 | |
| SCHEMBL3382655 | 0.73 | KDM4E (0.53) | ALDH1A1SMN1; SMN2KDM4EMAPTNPC1 | |
| SCHEMBL12056713 | 0.70 | ALOX5 (0.54) | ALDH1A1SMN1; SMN2KDM4EPOLBMAPT | |
| SCHEMBL13905565 | 0.70 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2KDM4EPOLBMAPT | |
| SCHEMBL8100226 | 0.69 | KDM4E (0.59) | ALDH1A1SMN1; SMN2KDM4EPOLBMAPT | |
| SCHEMBL5750125 | 0.68 | KDM4E (0.50) | ALDH1A1SMN1; SMN2KDM4EPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002002557-A2 | 2-PHENYLIMIDAZO[1,2-A]PYRIDINE DERIVATIVES: A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2002-01-10 | — | — | WO | claimed |
| WO-2002002557-A2 | 2-PHENYLIMIDAZO[1,2-A]PYRIDINE DERIVATIVES: A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2002-01-10 | — | — | WO | disclosed |