Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 14/20 | 0.48 |
| ▸ | CTSL | P07711 | 14/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 8/20 | 0.47 |
| ▸ | CTSB | P07858 | 7/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7379125 | 0.85 | CTSS (0.45) | CTSSCTSLTACR1CTSKCTSB | |
| SCHEMBL7379128 | 0.81 | CTSS (0.53) | CTSSCTSLTACR1CTSKCTSB | |
| SCHEMBL7380852 | 0.81 | CTSS (0.42) | CTSSCTSLTACR1CTSKCTSB | |
| SCHEMBL2479865 | 0.76 | CASP1 (0.49) | — | |
| SCHEMBL2479868 | 0.76 | CASP1 (0.49) | — | |
| SCHEMBL11475132 | 0.75 | ATM (0.53) | CTSSCTSLTACR1CTSK | |
| SCHEMBL6062814 | 0.74 | CTSC (0.40) | CTSSCTSLCTSKCTSB | |
| SCHEMBL6649637 | 0.74 | CTSC (0.40) | CTSSCTSLCTSKCTSB | |
| SCHEMBL19062411 | 0.74 | CTRB1 (0.62) | CTSSCTSLTACR1CTSKCTSB | |
| SCHEMBL6063016 | 0.73 | CTSC (0.43) | CTSSCTSLCTSKCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155011-A1 | DI- AND TRIPEPTIDE NITRILE DERIVATIVES AS INHIBITORS OF CATHEPSIN L AND CATHEPSIN S | AstraZeneca AB (SE) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000049008-A1 | DI- AND TRIPEPTIDE NITRILE DERIVATIVES AS INHIBITORS OF CATHEPSIN L AND CATHEPSIN S | ASTRAZENECA AB (SE) | 2000-08-24 | — | — | WO | disclosed |