Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 8/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6649637 | 0.82 | CTSC (0.40) | CTSCCTSLTP53LMNACTSS | |
| SCHEMBL6062814 | 0.82 | CTSC (0.40) | CTSCCTSLTP53LMNACTSS | |
| SCHEMBL6739717 | 0.81 | CTSC (0.48) | CTSCCTSLTP53LMNACTSS | |
| SCHEMBL6063011 | 0.80 | CTSC (0.38) | CTSCCTSLTP53LMNACTSS | |
| SCHEMBL7375289 | 0.73 | CTSS (0.48) | CTSLCTSSCTSKCTSB | |
| SCHEMBL7664906 | 0.71 | GSK3B (0.44) | CTSCLMNATSHRALDH1A1 | |
| SCHEMBL7666709 | 0.71 | ALOX5 (0.38) | CTSCCTSLTP53LMNATSHR | |
| SCHEMBL7701579 | 0.70 | ALOX5 (0.43) | CTSCCTSLTP53LMNACYP3A4 | |
| SCHEMBL7379125 | 0.70 | CTSS (0.45) | CTSLCTSSCTSKCTSB | |
| SCHEMBL31338919 | 0.69 | GLA (0.39) | CTSCCTSLLMNACYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694357-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005058348-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2005-06-30 | — | — | WO | disclosed |