Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.50 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.50 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.50 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25822003 | 0.85 | MAPT (0.46) | MAPTGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL9335542 | 0.80 | MAPK14 (0.39) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1ALK | |
| SCHEMBL3862889 | 0.76 | ALDH1A1 (0.44) | MAPTGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL4221657 | 0.72 | HPGD (0.68) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1ALK | |
| SCHEMBL13977986 | 0.71 | AURKA (0.46) | MAPTGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL21311923 | 0.70 | ALOX15 (0.46) | MAPTGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL30336 | 0.69 | MAPT (0.47) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1MAPT | |
| SCHEMBL25826396 | 0.69 | HPGD (0.53) | MAPTALDH1A1KMT2AMEN1MAPK1 | |
| SCHEMBL4730262 | 0.69 | TSHR (0.47) | MAPTALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL27500826 | 0.69 | MEN1 (0.56) | MAPTALDH1A1KMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814651-A | PHOSPHODIESTERASE TYPE FOUR INHIBITORS | PFIZER INC. (US) | 1998-09-29 | — | — | US | disclosed |
| EP-0672031-A1 | CATECHOL DIETHERS AS SELECTIVE PDE IV? INHIBITORS | PFIZER INC. (US) | 1995-09-20 | — | — | EP | disclosed |
| CN-1094028-A | Selective PDE enzyme (IV) inhibitor catechol diether class | PFIZER (US) | 1994-10-26 | — | — | CN | disclosed |
| WO-1994012461-A1 | CATECHOL DIETHERS AS SELECTIVE PDEIV INHIBITORS | PFIZER INC. (US) | 1994-06-09 | — | — | WO | disclosed |