Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6955598 | 0.88 | SMN1; SMN2 (0.47) | SMN1; SMN2POLBL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL9039893 | 0.88 | LMNA (0.43) | SMN1; SMN2POLBL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL6960622 | 0.84 | SMN1; SMN2 (0.49) | SMN1; SMN2POLBL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL6961275 | 0.82 | KDM4E (0.44) | SMN1; SMN2POLBL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL6956056 | 0.80 | TNKS (0.47) | SMN1; SMN2POLBL3MBTL1NPC1RAB9A | |
| SCHEMBL6954657 | 0.79 | SMN1; SMN2 (0.44) | SMN1; SMN2POLBL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL6956148 | 0.78 | PTGES (0.45) | SMN1; SMN2POLBL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL6963458 | 0.78 | SMN1; SMN2 (0.46) | SMN1; SMN2POLBL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL6959678 | 0.77 | SMN1; SMN2 (0.42) | SMN1; SMN2POLBL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL6964030 | 0.77 | SMN1; SMN2 (0.45) | SMN1; SMN2POLBL3MBTL1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729465-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014013-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1995-05-26 | — | — | WO | disclosed |