Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6964784 | 0.89 | L3MBTL1 (0.43) | LMNAALDH1A1L3MBTL1POLBSMN1; SMN2 | |
| SCHEMBL7375386 | 0.88 | SMN1; SMN2 (0.45) | ALDH1A1L3MBTL1POLBSMN1; SMN2MEN1 | |
| SCHEMBL6965449 | 0.86 | PTGER4 (0.39) | LMNAALDH1A1POLBSMN1; SMN2TSHR | |
| SCHEMBL6961275 | 0.84 | KDM4E (0.44) | ALDH1A1L3MBTL1POLBSMN1; SMN2TSHR | |
| SCHEMBL6960622 | 0.79 | SMN1; SMN2 (0.49) | ALDH1A1L3MBTL1POLBSMN1; SMN2TNKS | |
| SCHEMBL6959999 | 0.78 | NTRK1 (0.46) | LMNAALDH1A1L3MBTL1POLBSMN1; SMN2 | |
| SCHEMBL6955598 | 0.77 | SMN1; SMN2 (0.47) | LMNAALDH1A1L3MBTL1POLBSMN1; SMN2 | |
| SCHEMBL6957750 | 0.77 | ABCB1 (0.44) | ALDH1A1L3MBTL1POLBSMN1; SMN2TSHR | |
| SCHEMBL6958824 | 0.77 | TNKS (0.48) | LMNAALDH1A1L3MBTL1POLBSMN1; SMN2 | |
| SCHEMBL8538393 | 0.77 | POLB (0.43) | LMNAALDH1A1L3MBTL1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729466-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014014-A2 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1995-05-26 | — | — | WO | disclosed |