Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | CYP2E1 | P05181 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367119 | 0.87 | MAPK14 (0.39) | RAF1 | |
| SCHEMBL7377115 | 0.84 | NPY5R (0.57) | CYP11B1CYP11B2CYP2E1CYP3A4CYP2A6 | |
| SCHEMBL7369709 | 0.81 | CYP11B1 (0.43) | CYP11B1CYP11B2CYP2E1CYP3A4CYP2A6 | |
| SCHEMBL7372971 | 0.79 | NPY5R (0.41) | CYP11B1CYP11B2CYP2E1CYP3A4CYP2A6 | |
| SCHEMBL7369854 | 0.79 | CYP11B1 (0.48) | CYP11B1CYP11B2KDM4ENPC1MAPT | |
| SCHEMBL10564774 | 0.77 | CYP11B2 (0.43) | CYP11B1CYP11B2KDM4ENPC1MAPT | |
| SCHEMBL7372367 | 0.76 | CYP11B2 (0.45) | CYP11B1CYP11B2CYP3A4KDM4ENPC1 | |
| SCHEMBL9634600 | 0.76 | PDE5A (0.40) | KDM4ENPC1RAB9AKITSMN1; SMN2 | |
| SCHEMBL7366314 | 0.75 | MAPK13 (0.54) | CYP11B1CYP11B2CYP3A4CYP2C19KDM4E | |
| Hydrochloric Acid SCHEMBL9838295 | 0.75 | PDE5A (0.41) | KDM4ENPC1RAB9AKITSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4822805-A | ANTIINFLAMMATORY AGENTS, CARDIOTONIC AGENTS, ANTIPLATELET AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| EP-0257897-A1 | Imidazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-02 | — | — | EP | disclosed |