Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7368767 | 0.83 | MEN1 (0.61) | TRPM8CHRM2CHRM3CYP2D6NPC1 | |
| SCHEMBL29275128 | 0.78 | TRPM8 (0.58) | TRPM8CHRM2CHRM3CYP2D6SLC6A9 | |
| SCHEMBL10455127 | 0.76 | LMNA (0.60) | TRPM8SLC6A9NPC1MAPK1KDM4E | |
| SCHEMBL7376311 | 0.76 | HSD17B1 (0.57) | NPC1MAPK1KDM4EHPGDRAB9A | |
| SCHEMBL7378825 | 0.76 | RAB9A (0.62) | TRPM8CHRM2CHRM3NPC1RAB9A | |
| SCHEMBL11406234 | 0.75 | KMT2A (0.64) | TRPM8SLC6A9NPC1HPGDRAB9A | |
| SCHEMBL10454995 | 0.75 | KMT2A (0.64) | TRPM8SLC6A9NPC1HPGDRAB9A | |
| SCHEMBL2114776 | 0.74 | CHRM2 (0.54) | TRPM8CHRM2CHRM3NPC1KDM4E | |
| SCHEMBL11807077 | 0.74 | LMNA (0.50) | TRPM8CHRM2CHRM3OPRD1NPC1 | |
| SCHEMBL8428737 | 0.74 | TRPM8 (0.51) | TRPM8CHRM2CHRM3OPRD1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211242-B1 | CARDIOVASCULAR DISORDERS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-0757670-B1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-01-13 | — | — | EP | disclosed |
| EP-0757670-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-02-12 | — | — | EP | disclosed |
| WO-1995029152-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-11-02 | — | — | WO | disclosed |