Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.61 |
| ▸ | PDE4A | P27815 | 14/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 14/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420740 | 0.77 | PDE4A (0.66) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL8344453 | 0.76 | PDE4B (0.71) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL7869812 | 0.76 | PDE4B (0.76) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL7416733 | 0.76 | PDE4B (1.00) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL7181002 | 0.76 | PDE4B (0.82) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7362543 | 0.76 | PDE4B (0.69) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL7796189 | 0.76 | PDE4A (0.73) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7796186 | 0.76 | PDE4A (0.73) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6323001 | 0.75 | PDE4B (0.74) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL6322447 | 0.75 | PDE4B (0.74) | PDE4BPDE4DPDE4APDE4CPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994027947-A1 | PHENYLCYCLOPROPANE COMPOUNDS AND THEIR USE AS cAMP AND TNF INHIBITORS | RHONE-POULENC RORER LTD. (GB) | 1994-12-08 | — | — | WO | claimed |
| WO-1994027947-A1 | PHENYLCYCLOPROPANE COMPOUNDS AND THEIR USE AS cAMP AND TNF INHIBITORS | RHONE-POULENC RORER LTD. (GB) | 1994-12-08 | — | — | WO | disclosed |