Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.66 |
| ▸ | PDE4C | Q08493 | 14/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | SELP | P16109 | 3/20 | 0.54 |
| ▸ | SELL | P14151 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6708835 | 0.86 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL21051103 | 0.86 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL9260618 | 0.82 | LMNA (0.70) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL6322447 | 0.81 | PDE4B (0.74) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL6322995 | 0.81 | PDE4B (0.74) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL6323001 | 0.81 | PDE4B (0.74) | PDE4APDE4BPDE4CPDE4DLMNA | |
| Bicarbonate SCHEMBL4603657 | 0.81 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7416733 | 0.80 | PDE4B (1.00) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7869812 | 0.80 | PDE4B (0.76) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL77742 | 0.79 | LMNA (0.65) | PDE4APDE4BPDE4CPDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016134668-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2016-09-01 | — | — | WO | disclosed |
| WO-2016000615-A1 | HETEROARYL COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2016-01-07 | — | — | WO | disclosed |
| EP-0714293-A4 | 3-CYANO-3-(3,4-DISUBSTITUTED)PHENYLCYCLOHEXYL-1-CARBOXYLATES | SMITHKLINE BEECHAM CORP (US) | 1999-04-07 | — | — | EP | disclosed |
| US-5602157-A | Compounds useful for treating allergic and inflammatory diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1997-02-11 | — | — | US | disclosed |
| EP-0714293-A1 | 3-CYANO-3-(3,4-DISUBSTITUTED)PHENYLCYCLOHEXYL-1-CARBOXYLATES | SMITHKLINE BEECHAM CORPORATION (US) | 1996-06-05 | — | — | EP | disclosed |
| WO-1995003794-A1 | 3-CYANO-3-(3,4-DISUBSTITUTED)PHENYLCYCLOHEXYL-1-CARBOXYLATES | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-09 | — | — | WO | disclosed |