Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SGMS2 | Q8NHU3 | 4/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 4/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7380650 | 0.80 | SGMS2 (0.53) | CAPN1SGMS2POLBALDH1A1RAB9A | |
| SCHEMBL1346595 | 0.78 | SGMS2 (0.58) | LMNAHTTSGMS2RXFP1POLB | |
| SCHEMBL7377431 | 0.76 | CAPN1 (0.48) | CAPN1SGMS2RXFP1CTSSCTSK | |
| SCHEMBL1346892 | 0.75 | ALDH1A1 (0.56) | LMNAHTTSGMS2RXFP1POLB | |
| SCHEMBL7164758 | 0.73 | ALDH1A1 (0.55) | HTTSGMS2NPC1ALDH1A1GAA | |
| SCHEMBL15941086 | 0.73 | SGMS2 (0.55) | CAPN1LMNASGMS2CTSKNPC1 | |
| SCHEMBL1346671 | 0.71 | SGMS2 (0.66) | HTTSGMS2RXFP1NPC1GAA | |
| SCHEMBL7791324 | 0.70 | CAPN1 (1.00) | CAPN1LMNAHTTSGMS2NPC1 | |
| SCHEMBL7791328 | 0.70 | CAPN1 (1.00) | CAPN1LMNAHTTSGMS2NPC1 | |
| SCHEMBL7787025 | 0.70 | CAPN1 (0.52) | CAPN1LMNANPC1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251917-B1 | Benzamidoaldehydes and their use as cysteine protease inhibitors | BASF AKTIENGESELLSCHAFT (DE) | 2001-06-26 | — | — | US | disclosed |
| EP-0944584-A1 | BENZAMIDOALDEHYDES AND THEIR USE AS CYSTEINE PROTEASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998023581-A1 | BENZAMIDOALDEHYDES AND THEIR USE AS CYSTEINE PROTEASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 1998-06-04 | — | — | WO | disclosed |