Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7458374 | 0.91 | GAA (0.56) | GAAROCK2EPHX2CYP4F2CYP4A11 | |
| SCHEMBL7864682 | 0.86 | GAA (0.55) | GAARAB9AROCK2EPHX2ALOX5 | |
| SCHEMBL6881434 | 0.80 | FFAR1 (0.52) | GAACYP4F2CYP4A11POLB | |
| SCHEMBL12988864 | 0.77 | L3MBTL1 (0.63) | GAARAB9ANPC1ROCK2NAMPT | |
| SCHEMBL4506493 | 0.77 | CYP4F2 (0.66) | RAB9ACYP4F2CYP4A11MAPT | |
| SCHEMBL9267010 | 0.76 | RAB9A (0.62) | GAARAB9ANPC1EPHX2MAPT | |
| SCHEMBL3984665 | 0.76 | GAA (0.64) | GAARAB9ANPC1ROCK2NAMPT | |
| SCHEMBL6359399 | 0.75 | SMN1; SMN2 (0.72) | GAANAMPTMAPTHDAC3SMN1; SMN2 | |
| SCHEMBL1659817 | 0.75 | GSK3B (0.57) | GAASMN1; SMN2GPR139GRM5MEN1 | |
| SCHEMBL8497478 | 0.74 | LMNA (0.53) | GAARAB9ANPC1MAPTHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891325-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036859-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | disclosed |