Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLH | Q9Y253 | 2/20 | 0.61 |
| ▸ | QPCT | Q16769 | 2/20 | 0.60 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.59 |
| ▸ | XDH | P47989 | 6/20 | 0.57 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | MAOA | P21397 | 2/20 | 0.57 |
| ▸ | MAOB | P27338 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10433113 | 0.82 | SIGMAR1 (0.59) | CYP1A1CYP1A2MAOBSIGMAR1CYP2B6 | |
| SCHEMBL433900 | 0.82 | EGFR (0.71) | ABCB1CYP1A1CYP1A2CYP3A4MAPT | |
| SCHEMBL16823312 | 0.81 | EGFR (0.70) | ABCB1MAPTSIGMAR1EGFRRET | |
| SCHEMBL431393 | 0.80 | EGFR (0.69) | SIGMAR1EGFRRETKDR | |
| SCHEMBL4152555 | 0.77 | ABCB1 (0.93) | POLHQPCTABCB1XDHCYP1A1 | |
| SCHEMBL31291006 | 0.77 | POLH (1.00) | POLHQPCTABCB1XDHCYP1A1 | |
| SCHEMBL30335147 | 0.77 | POLH (1.00) | POLHQPCTABCB1XDHCYP1A1 | |
| Chrysin SCHEMBL28168227 | 0.75 | MAPT (0.89) | POLHQPCTABCB1XDHCYP1A1 | |
| SCHEMBL4152249 | 0.74 | ABCB1 (1.00) | POLHQPCTABCB1XDHCYP1A1 | |
| SCHEMBL4156163 | 0.74 | ABCB1 (1.00) | POLHQPCTABCB1XDHCYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115718-A1 | HYDROXYFLAVONE DERIVATIVES AS TAU PROTEIN KINASE 1 INHIBITORS | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000017184-A1 | HYDROXYFLAVONE DERIVATIVES AS TAU PROTEIN KINASE 1 INHIBITORS | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-03-30 | — | — | WO | disclosed |