Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6957845 | 0.90 | ALDH1A1 (0.50) | ALDH1A1CRHBPCRHR2LMNAMAPT | |
| SCHEMBL7419641 | 0.86 | ALDH1A1 (0.52) | ALDH1A1CRHBPCRHR2LMNAMAPT | |
| SCHEMBL7417406 | 0.83 | ALDH1A1 (0.70) | ALDH1A1CRHBPCRHR2LMNAMAPT | |
| SCHEMBL7367843 | 0.83 | NPSR1 (0.49) | ALDH1A1NPSR1LMNAMAPTKDM4E | |
| SCHEMBL7372075 | 0.80 | CRHBP (0.65) | ALDH1A1NPSR1CRHBPCRHR2LMNA | |
| SCHEMBL7422213 | 0.79 | ALDH1A1 (0.54) | ALDH1A1CRHBPCRHR2LMNAMAPT | |
| SCHEMBL3453497 | 0.78 | CRHBP (0.70) | ALDH1A1CRHBPCRHR2LMNAMAPT | |
| SCHEMBL7416266 | 0.77 | ALDH1A1 (0.54) | ALDH1A1LMNAMAPTKDM4EKMT2A | |
| SCHEMBL8103391 | 0.76 | ALDH1A1 (0.53) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL7371730 | 0.76 | CRHBP (0.51) | ALDH1A1CRHBPCRHR2MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211242-B1 | CARDIOVASCULAR DISORDERS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-0757670-B1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-01-13 | — | — | EP | disclosed |
| EP-0757670-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-02-12 | — | — | EP | disclosed |
| WO-1995029152-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-11-02 | — | — | WO | disclosed |