SCHEMBL7376151

SCHEMBL7376151

CC(=O)C(Cc1ccccc1C(F)(F)F)[N+](=O)[O-]

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.43
MAOA P21397 1/20 0.43
PPARG P37231 5/20 0.42
PPARA Q07869 1/20 0.42
POLQ O75417 1/20 0.42
EPHX2 P34913 4/20 0.39
DPP4 P27487 2/20 0.39
DPP7 Q9UHL4 1/20 0.39
ALDH1A1 P00352 2/20 0.39
KDM4E B2RXH2 1/20 0.39
GAA P10253 1/20 0.39
ATM Q13315 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
POLB P06746 1/20 0.38
MAPK1 P28482 1/20 0.38
SLC6A2 P23975 2/20 0.37
SLC6A4 P31645 2/20 0.37
IDO1 P14902 1/20 0.37
CTNNB1 P35222 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6695640 0.79 PPARG (0.51) MAOBMAOAPPARGPPARAPOLQ
SCHEMBL16509236 0.74 MAOA (0.45) MAOBMAOAPPARGPPARAPOLQ
SCHEMBL9492298 0.72 PPARG (0.57) PPARGPPARAPOLQEPHX2DPP4
SCHEMBL14208224 0.71 PPARG (0.62) MAOBMAOAPPARGPPARAPOLQ
SCHEMBL7375299 0.70 EPHX2 (0.59) PPARGPPARAPOLQEPHX2CTNNB1
SCHEMBL31402799 0.70 POLQ (0.56) MAOBMAOAPOLQEPHX2ALDH1A1
SCHEMBL265536 0.70 POLQ (0.59) MAOBMAOAPOLQEPHX2ALDH1A1
SCHEMBL2426168 0.70 IDO1 (0.47) MAOBMAOAPPARGPPARAPOLQ
SCHEMBL31173765 0.70 POLQ (0.59) MAOBMAOAPOLQEPHX2ALDH1A1
SCHEMBL16534653 0.70 IDO1 (0.47) MAOBMAOAPPARGPPARAPOLQ

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4876254-A CARDIOVASCULAR DISORDERS, HYPERTENSIVE AGENTS, ANTIARRHYTHMIA AGENTS BAYER AKTIENGESELLSCHAFT (DE) 1989-10-24 US disclosed
EP-0287867-A1 Substituted 5-nitro-1,4-dihydropyridines, method for their preparation and their use BAYER AG (DE) 1988-10-26 EP disclosed