Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 4/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.45 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | ALPI | P09923 | 1/20 | 0.43 |
| ▸ | ALPG | P10696 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8846224 | 0.88 | RECQL (0.55) | PDE4BRECQLPOLBPDE4APDE4C | |
| SCHEMBL2958828 | 0.85 | RECQL (0.60) | PDE4BRECQLPOLBPDE4APDE4C | |
| SCHEMBL134754 | 0.82 | RECQL (0.67) | PDE4BRECQLPOLBPDE4APDE4C | |
| SCHEMBL7925327 | 0.82 | RECQL (0.48) | HTTPDE4BPDE3ARECQLPDE4A | |
| SCHEMBL697888 | 0.81 | HTT (0.61) | HTTPDE3APOLBPDE4APDE4D | |
| SCHEMBL6812898 | 0.79 | PDE4D (0.56) | PDE4BRECQLPDE4APDE4CPDE4D | |
| SCHEMBL682485 | 0.79 | POLB (0.57) | PDE4BPDE3APOLBPDE4APDE4C | |
| SCHEMBL7940494 | 0.78 | RECQL (0.43) | HTTPDE4BPDE3ARECQLPOLB | |
| SCHEMBL16952573 | 0.77 | HTT (0.49) | HTTALDH1A1CYP1A2MAPTCYP2C9 | |
| SCHEMBL15904183 | 0.77 | CSNK2A1 (0.48) | PDE4BRECQLPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0796093-A4 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | EURO CELTIQUE SA (LU) | 1998-05-13 | — | — | EP | disclosed |
| EP-0796093-A1 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | Euroceltique S.A. (LU) | 1997-09-24 | — | — | EP | disclosed |
| WO-1996021435-A1 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | EURO-CELTIQUE, S.A. (LU) | 1996-07-18 | — | — | WO | disclosed |