Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | STK17B | O94768 | 1/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.33 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6059420 | 0.96 | L3MBTL1 (0.38) | L3MBTL1MKNK2KMT2AMEN1LMNA | |
| Diethylamine SCHEMBL7375213 | 0.89 | PPARG (0.33) | MKNK2MAPKAPK2PPARG | |
| SCHEMBL6059174 | 0.84 | PPARG (0.34) | MKNK2MAPKAPK2PPARG | |
| Diethylamine SCHEMBL7380494 | 0.81 | NAMPT (0.41) | MKNK2POLBMAPKAPK2MAPTALDH1A1 | |
| SCHEMBL6059446 | 0.77 | CPB2 (0.41) | L3MBTL1MKNK2KMT2AMEN1LMNA | |
| SCHEMBL3820976 | 0.76 | NAMPT (0.43) | MKNK2KMT2AMEN1POLBMAPT | |
| SCHEMBL6059152 | 0.76 | STK17B (0.42) | L3MBTL1KMT2AMEN1STK17BSTK17A | |
| SCHEMBL6060000 | 0.76 | CPB2 (0.39) | L3MBTL1MKNK2KMT2AMEN1LMNA | |
| SCHEMBL6058971 | 0.75 | STK17B (0.41) | L3MBTL1KMT2AMEN1STK17BSTK17A | |
| Malonic Acid Diethyl Ester SCHEMBL7380709 | 0.74 | L3MBTL1 (0.41) | L3MBTL1MKNK2KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1180098-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2002-02-20 | — | — | EP | disclosed |
| WO-2000066557-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2000-11-09 | — | — | WO | disclosed |