Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6042880 | 0.81 | KMT2A (0.45) | LMNASMN1; SMN2TLR9TP53NPC1 | |
| SCHEMBL22400987 | 0.80 | LMNA (0.43) | LMNASMN1; SMN2TLR9TP53NPC1 | |
| SCHEMBL2350715 | 0.78 | MAPT (0.42) | LMNASMN1; SMN2TLR9TP53NPC1 | |
| SCHEMBL31726565 | 0.76 | KDR (0.44) | LMNASMN1; SMN2TP53NPSR1ALDH1A1 | |
| SCHEMBL15633418 | 0.76 | PTGS2 (0.43) | LMNASMN1; SMN2TLR9TP53NPC1 | |
| SCHEMBL25243394 | 0.76 | KDR (0.44) | LMNASMN1; SMN2TP53NPSR1ALDH1A1 | |
| SCHEMBL25234983 | 0.76 | KDM4E (0.40) | LMNASMN1; SMN2TLR9TP53NPC1 | |
| SCHEMBL12479725 | 0.74 | LMNA (0.52) | LMNASMN1; SMN2TP53NPSR1ALDH1A1 | |
| SCHEMBL14800642 | 0.74 | ALDH1A1 (0.58) | LMNASMN1; SMN2TLR9TP53NPC1 | |
| SCHEMBL22489959 | 0.73 | TP53 (0.46) | LMNASMN1; SMN2TLR9TP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1196394-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES WITH 5,6 SUBSTITUTED PYRIMIDINE RING, THE PRODUCTION AND UTILIZATION THEREOF AS ENDOTHELIN RECEPTOR ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001005771-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES WITH 5,6 SUBSTITUTED PYRIMIDINE RING, THE PRODUCTION AND UTILIZATION THEREOF AS ENDOTHELIN RECEPTOR ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 2001-01-25 | — | — | WO | disclosed |