Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.40 |
| ▸ | CPA1 | P15085 | 2/20 | 0.40 |
| ▸ | CPA3 | P15088 | 2/20 | 0.40 |
| ▸ | CPB1 | P15086 | 1/20 | 0.40 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6775970 | 0.83 | GPR132 (0.49) | GPR132ITGB3ITGA2B | |
| SCHEMBL7864776 | 0.83 | PPARG (0.53) | LMNAPPARGEPHX2 | |
| SCHEMBL7372216 | 0.82 | F10 (0.43) | F10PRSS1PPARGCYP1A2EPHX2 | |
| SCHEMBL8500048 | 0.82 | LMNA (0.50) | F10PRSS1LMNAPPARGCYP1A2 | |
| SCHEMBL7376324 | 0.81 | GPR132 (0.49) | GPR132ITGB3ITGA2B | |
| SCHEMBL7376317 | 0.81 | GPR132 (0.49) | GPR132ITGB3ITGA2B | |
| SCHEMBL7457847 | 0.80 | MEN1 (0.51) | LMNAPPARGITGB3ITGA2B | |
| SCHEMBL7823171 | 0.79 | ITGB3 (0.50) | GPR132CPA1ITGB3ITGA2B | |
| SCHEMBL7864788 | 0.79 | SIRT2 (0.44) | LMNAPPARGSIRT2EPHX2 | |
| SCHEMBL7864267 | 0.78 | TP53 (0.45) | LMNAPPARGSIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891325-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-01-20 | — | — | EP | claimed |
| WO-1997036859-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |