Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.39 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7382482 | 0.83 | CA12 (0.47) | SMN1; SMN2MAPTNPC1ALDH1A1KMT2A | |
| SCHEMBL7388942 | 0.82 | ALOX5 (0.43) | SMN1; SMN2PRKCZMAPTNPC1ALDH1A1 | |
| SCHEMBL7382857 | 0.81 | MAPT (0.43) | SMN1; SMN2PRKCZMAPTNPC1ALDH1A1 | |
| SCHEMBL5209415 | 0.81 | CCR2 (0.43) | SMN1; SMN2MAPTNPC1ALDH1A1KMT2A | |
| SCHEMBL7697013 | 0.81 | NPC1 (0.41) | SMN1; SMN2MAPTNPC1ALDH1A1KMT2A | |
| SCHEMBL7380758 | 0.81 | CA12 (0.47) | MAPTNPC1ALDH1A1KMT2AMAPK1 | |
| SCHEMBL7702467 | 0.81 | SMN1; SMN2 (0.45) | SMN1; SMN2MAPTNPC1ALDH1A1KMT2A | |
| SCHEMBL5550241 | 0.80 | ALDH1A1 (0.52) | MAPTNPC1ALDH1A1KMT2A | |
| SCHEMBL7377049 | 0.80 | NPC1 (0.41) | SMN1; SMN2PRKCZMAPTSLC6A2SLC6A4 | |
| SCHEMBL7698975 | 0.79 | CA12 (0.52) | SMN1; SMN2MAPTNPC1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998055475-A1 | GUANIDINE DERIVIATIVES AS INHIBITORS OF NA+/H+ EXCHANGE IN CELLS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-12-10 | — | — | WO | disclosed |