Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7679128 | 0.91 | CCR5 (0.46) | MAPTNPC1RAB9ACLK1CCR5 | |
| SCHEMBL7385872 | 0.90 | CA12 (0.47) | CA12CA9CA2MEN1KMT2A | |
| SCHEMBL7382482 | 0.90 | CA12 (0.47) | CA12CA9MEN1KMT2AMAPT | |
| SCHEMBL7388942 | 0.86 | ALOX5 (0.43) | MEN1KMT2AMAPTLMNAKDM4E | |
| SCHEMBL7700889 | 0.86 | CA12 (0.63) | CA12CA9CA2MEN1KMT2A | |
| SCHEMBL7697013 | 0.85 | NPC1 (0.41) | MEN1KMT2AMAPTLMNAKDM4E | |
| SCHEMBL5209415 | 0.85 | CCR2 (0.43) | MEN1KMT2AMAPTLMNAKDM4E | |
| SCHEMBL7382857 | 0.85 | MAPT (0.43) | MEN1KMT2AMAPTLMNAKDM4E | |
| SCHEMBL5550241 | 0.84 | ALDH1A1 (0.52) | CA12CA9CA2MEN1KMT2A | |
| SCHEMBL7698975 | 0.83 | CA12 (0.52) | CA12CA9MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998055475-A1 | GUANIDINE DERIVIATIVES AS INHIBITORS OF NA+/H+ EXCHANGE IN CELLS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-12-10 | — | — | WO | disclosed |