Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 13/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 13/20 | 0.51 |
| ▸ | P2RY12 | Q9H244 | 5/20 | 0.41 |
| ▸ | SGK1 | O00141 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | ROS1 | P08922 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7382397 | 0.88 | PDE3B (0.53) | PDE3BPDE3AP2RY12SGK1THRA | |
| SCHEMBL7378034 | 0.88 | PDE3B (0.55) | PDE3BPDE3ASGK1IKBKBCHUK | |
| SCHEMBL7377905 | 0.79 | PDE3B (0.64) | PDE3BPDE3AIKBKBCHUKKIT | |
| SCHEMBL7385190 | 0.76 | PDE3B (0.58) | PDE3BPDE3A | |
| SCHEMBL7387266 | 0.75 | MEN1 (0.59) | PDE3BPDE3AKIT | |
| SCHEMBL7383419 | 0.74 | PDE3B (0.70) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL7417690 | 0.73 | PDE3B (0.68) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL7426034 | 0.71 | PDE3B (0.60) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL7382885 | 0.70 | PDE3B (0.72) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL7386282 | 0.70 | PDE3B (0.72) | PDE3BPDE3AP2RY12PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5010086-A | Enzyme inhibitor for treating congestive heart failure or hypertension in mammals | STERLING DRUG INC. (US) | 1991-04-23 | — | — | US | disclosed |
| US-4963561-A | Phosphodiesterase inhibitors | STERLING DRUG INC. (US) | 1990-10-16 | — | — | US | disclosed |