Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.57 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.55 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.55 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.55 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.55 |
| ▸ | KIT | P10721 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7377905 | 0.84 | PDE3B (0.64) | MEN1KMT2APDE3BPDE3AKIT | |
| SCHEMBL7385190 | 0.81 | PDE3B (0.58) | MEN1KMT2APDE3BPDE3APTPN1 | |
| SCHEMBL7383419 | 0.79 | PDE3B (0.70) | PDE3BPDE3A | |
| SCHEMBL7378034 | 0.78 | PDE3B (0.55) | PDE3BPDE3APTPN5KITALDH1A1 | |
| SCHEMBL7380456 | 0.77 | MEN1 (0.53) | MEN1KMT2APDE3BPDE3AALDH1A1 | |
| SCHEMBL7382397 | 0.76 | PDE3B (0.53) | PDE3BPDE3AKITKDM4EHPGD | |
| SCHEMBL7382885 | 0.75 | PDE3B (0.72) | PDE3BPDE3A | |
| SCHEMBL7386282 | 0.75 | PDE3B (0.72) | PDE3BPDE3A | |
| SCHEMBL22425029 | 0.75 | KMT2A (0.84) | MEN1KMT2AALDH1A1PKMMAPK1 | |
| SCHEMBL7384334 | 0.75 | PDE3B (0.64) | MEN1KMT2APDE3BPDE3AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4963561-A | Phosphodiesterase inhibitors | STERLING DRUG INC. (US) | 1990-10-16 | — | — | US | claimed |
| US-5010086-A | Enzyme inhibitor for treating congestive heart failure or hypertension in mammals | STERLING DRUG INC. (US) | 1991-04-23 | — | — | US | disclosed |