Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7299641 | 0.84 | HRH4 (0.33) | — | |
| SCHEMBL7300381 | 0.83 | LMNA (0.31) | — | |
| SCHEMBL7297986 | 0.81 | CYP2E1 (0.31) | CDK8 | |
| SCHEMBL7300635 | 0.81 | TNKS (0.30) | — | |
| SCHEMBL7368755 | 0.80 | NPC1 (0.33) | — | |
| SCHEMBL7376892 | 0.80 | — | — | |
| SCHEMBL7300227 | 0.78 | MEN1 (0.37) | CDK8 | |
| SCHEMBL7292929 | 0.78 | NPBWR1 (0.30) | — | |
| SCHEMBL7297727 | 0.78 | TDP1 (0.37) | — | |
| SCHEMBL7292763 | 0.78 | SMN1; SMN2 (0.36) | CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0308792-B1 | AZACHROMANE DERIVATIVES | MERCK PATENT GmbH (DE) | 1993-07-28 | — | — | EP | disclosed |
| US-4931454-A | Azachroman derivatives with effects on the cardiovascular system | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-06-05 | — | — | US | disclosed |