Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7373058 | 0.84 | ALDH1A1 (0.45) | PLAUKMT2AJAK2ROCK2TYK2 | |
| SCHEMBL7590438 | 0.84 | ALDH1A1 (0.45) | PLAUKMT2AJAK2ROCK2TYK2 | |
| Hydrochloric Acid SCHEMBL7366884 | 0.83 | ALDH1A1 (0.44) | PLAUKMT2AJAK2ROCK2TYK2 | |
| SCHEMBL7378281 | 0.80 | ADAM17 (0.37) | PLAUADAM17LMNAGAAITGB1 | |
| SCHEMBL6434675 | 0.80 | ADAM17 (0.37) | PLAUADAM17LMNAGAAITGB1 | |
| SCHEMBL6435150 | 0.80 | ADAM17 (0.37) | PLAUADAM17LMNAGAAITGB1 | |
| Hydrochloric Acid SCHEMBL6433470 | 0.80 | ADAM17 (0.36) | PLAUADAM17LMNAGAAITGB1 | |
| SCHEMBL7370379 | 0.79 | PLAU (0.54) | PLAUKDM4ELMNAPKMALDH1A1 | |
| Hydrochloric Acid SCHEMBL7369169 | 0.78 | PLAU (0.54) | PLAUKDM4ELMNAPKMALDH1A1 | |
| SCHEMBL7365364 | 0.78 | PLAU (0.54) | PLAUKDM4ELMNAALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |