Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 3/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | F10 | P00742 | 3/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6435150 | 1.00 | ADAM17 (0.37) | ADAM17PLAUGAAF10F2 | |
| SCHEMBL6434675 | 1.00 | ADAM17 (0.37) | ADAM17PLAUGAAF10F2 | |
| Hydrochloric Acid SCHEMBL6433470 | 0.99 | ADAM17 (0.36) | ADAM17PLAUGAAF10F2 | |
| SCHEMBL7373053 | 0.84 | ALDH1A1 (0.45) | PLAULMNAALDH1A1TDP1 | |
| SCHEMBL7590429 | 0.84 | ALDH1A1 (0.45) | PLAULMNAALDH1A1TDP1 | |
| SCHEMBL6433528 | 0.84 | ALDH1A1 (0.45) | PLAULMNAALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL6434299 | 0.83 | ALDH1A1 (0.44) | PLAULMNAALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL6433791 | 0.83 | ALDH1A1 (0.44) | PLAULMNAALDH1A1TDP1 | |
| SCHEMBL7378285 | 0.80 | PLAU (0.38) | ADAM17PLAUGAAITGB1ITGA4 | |
| SCHEMBL7370376 | 0.78 | PLAU (0.53) | PLAUALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |