Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 9/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 8/20 | 0.50 |
| ▸ | LGMN | Q99538 | 1/20 | 0.43 |
| ▸ | F12 | P00748 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16149750 | 0.86 | PDE3A (0.55) | PDE3APDE3BPDE4BDGAT1ALDH1A1 | |
| SCHEMBL10668904 | 0.74 | PDE3B (0.49) | PDE3APDE3BPDE4BMAPTSMN1; SMN2 | |
| SCHEMBL10667501 | 0.73 | PDE3B (0.74) | PDE3APDE3BPDE4BALDH1A1MAPT | |
| SCHEMBL6074497 | 0.70 | LGMN (0.47) | LGMNF12ALDH1A1MAPTCYP2C9 | |
| SCHEMBL14117662 | 0.69 | LGMN (0.54) | LGMNALDH1A1MAPTSMN1; SMN2HPGD | |
| SCHEMBL2847376 | 0.68 | PDE3A (0.55) | PDE3APDE3BPDE4B | |
| SCHEMBL6132758 | 0.68 | LGMN (0.52) | LGMNALDH1A1USP2HSD17B10KDM4E | |
| SCHEMBL30817316 | 0.68 | LGMN (0.47) | LGMNF12RORCALDH1A1MAPT | |
| SCHEMBL7380645 | 0.67 | PDE3A (0.54) | PDE3APDE3BPDE4BALDH1A1SMN1; SMN2 | |
| SCHEMBL6074502 | 0.67 | MAPT (0.54) | LGMNF12ALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4661496-A | Cardiotonic and antihypertensive 2,4-dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones | WARNER-LAMBERT COMPANY (US) | 1987-04-28 | — | — | US | claimed |
| EP-0126651-A2 | 2,4-Dihydro-5-((substituted)phenyl)-4,4-disubstituted-3H-pyrazol-3-ones, 2,4-dihydro-5-((substituted)phenyl)-4, 4-disubstituted-3H-pyrazol-3-thiones, and a process for producing the same | WARNER-LAMBERT COMPANY (US) | 1984-11-28 | — | — | EP | claimed |
| US-4661496-A | Cardiotonic and antihypertensive 2,4-dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones | WARNER-LAMBERT COMPANY (US) | 1987-04-28 | — | — | US | disclosed |
| US-4550119-A | 2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones | WARNER-LAMBERT COMPANY (US) | 1985-10-29 | — | — | US | disclosed |
| US-4526982-A | 2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones | WARNER-LAMBERT COMPANY, A CORP. OF DEL. | 1985-07-02 | — | — | US | disclosed |
| EP-0126651-A2 | 2,4-Dihydro-5-((substituted)phenyl)-4,4-disubstituted-3H-pyrazol-3-ones, 2,4-dihydro-5-((substituted)phenyl)-4, 4-disubstituted-3H-pyrazol-3-thiones, and a process for producing the same | WARNER-LAMBERT COMPANY (US) | 1984-11-28 | — | — | EP | disclosed |