Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | DCAF1 | Q9Y4B6 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7381395 | 0.87 | CYP26A1 (0.45) | KDM4EDCAF1CYP26A1 | |
| SCHEMBL6755336 | 0.74 | KDM4E (0.50) | ALDH1A1KDM4EKMT2ARXFP1HPGD | |
| SCHEMBL7379959 | 0.72 | CYP26A1 (0.42) | ALDH1A1LMNAKDM4EHPGDCYP26A1 | |
| SCHEMBL7378110 | 0.72 | L3MBTL1 (0.45) | THRBL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL7215538 | 0.72 | SUCNR1 (0.40) | THRBALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7217812 | 0.70 | CTSA (0.43) | LMNAMEN1KMT2ADCAF1CYP26A1 | |
| SCHEMBL7335381 | 0.70 | ALDH1A1 (0.49) | THRBTP53L3MBTL1ALDH1A1LMNA | |
| SCHEMBL1144389 | 0.69 | KMT2A (0.52) | L3MBTL1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL1405716 | 0.69 | KMT2A (0.52) | L3MBTL1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL1144506 | 0.69 | KMT2A (0.52) | L3MBTL1ALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115724-A1 | QUINOLIZINONES AS INTEGRIN INHIBITORS | Shire Biochem Inc. (CA) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000017197-A1 | QUINOLIZINONES AS INTEGRIN INHIBITORS | BIOCHEM PHARMA INC. (US) | 2000-03-30 | — | — | WO | disclosed |