Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7383016 | 0.85 | EPHX2 (0.38) | ALDH1A1MMP2P2RX7EPHX2PRMT6 | |
| SCHEMBL7373894 | 0.85 | MAPT (0.33) | ALDH1A1MAPTMMP2P2RX7GRM5 | |
| SCHEMBL6737411 | 0.82 | GRM5 (0.39) | ALDH1A1MAPTP2RX7GRM5GRIN1 | |
| SCHEMBL7375591 | 0.75 | MMP2 (0.35) | MMP2P2RX7 | |
| SCHEMBL7379603 | 0.74 | P2RX7 (0.35) | ALDH1A1MAPTMMP2P2RX7EPHX2 | |
| SCHEMBL7383794 | 0.74 | SLC9A1 (0.31) | — | |
| SCHEMBL6739923 | 0.71 | — | — | |
| SCHEMBL6742710 | 0.71 | HPGD (0.31) | — | |
| SCHEMBL7378072 | 0.70 | AR (0.42) | ALDH1A1MAPTKDM4ECHRNB2CHRNA4 | |
| SCHEMBL6741105 | 0.70 | NOTUM (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165500-A1 | AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES,TNF-ALPHA,AND AGGRECANASE | Du Pont Pharmaceuticals Company (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059874-A1 | NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-10-12 | — | — | WO | disclosed |