Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7384999 | 0.81 | MMP2 (0.36) | MMP2P2RX7TBXAS1CYP1A2CYP2D6 | |
| SCHEMBL7383016 | 0.79 | EPHX2 (0.38) | MMP2P2RX7HTTCYP1A2CYP2D6 | |
| SCHEMBL7374908 | 0.77 | KCNA5 (0.52) | P2RX7KCNA5KCNH2HTTHTR1A | |
| SCHEMBL7379652 | 0.75 | ALDH1A1 (0.33) | MMP2P2RX7 | |
| SCHEMBL5139104 | 0.74 | GABRA1 (0.42) | KCNH2HTTHTR1ACYP1A2CYP2D6 | |
| SCHEMBL6961073 | 0.72 | HTR2A (0.37) | CYP1A2CYP2D6RAB9A | |
| SCHEMBL7373960 | 0.72 | PARP1 (0.33) | — | |
| SCHEMBL7381630 | 0.72 | FDPS (0.38) | MMP2P2RX7KCNA5KCNH2TBXAS1 | |
| SCHEMBL8726941 | 0.71 | LTA4H (0.52) | CYP1A2CYP2D6LTA4HCHRNA7 | |
| SCHEMBL6955545 | 0.71 | IDO1 (0.48) | KCNH2HTTHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165500-A1 | AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES,TNF-ALPHA,AND AGGRECANASE | Du Pont Pharmaceuticals Company (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059874-A1 | NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-10-12 | — | — | WO | disclosed |