Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 4/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL761672 | 0.96 | GSTP1 (0.40) | TP53MAOBMAOANAAAMEN1 | |
| SCHEMBL19795842 | 0.85 | ALDH1A1 (0.34) | TP53MEN1KMT2ALMNANPC1 | |
| SCHEMBL18011887 | 0.84 | MAPK1 (0.44) | MAOBMAOAMEN1KMT2ALMNA | |
| SCHEMBL18011890 | 0.82 | MDM2 (0.38) | MEN1KMT2AGRM2 | |
| SCHEMBL18012015 | 0.82 | STING1 (0.35) | MEN1KMT2ALMNANPC1ALDH1A1 | |
| SCHEMBL19795849 | 0.81 | MAPK1 (0.41) | MAOBMEN1KMT2ALMNANPC1 | |
| SCHEMBL18011728 | 0.81 | CYP19A1 (0.36) | MAOBMAOACYP1A2ALDH1A1HPGD | |
| SCHEMBL764348 | 0.80 | TP53 (0.35) | TP53MAOBMAOANAAAMEN1 | |
| SCHEMBL8444217 | 0.80 | TP53 (0.35) | TP53MAOBMAOANAAAMEN1 | |
| SCHEMBL5552934 | 0.78 | IDH1 (0.36) | MAOBMAOAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210171507-A1 | SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYLTRANSFERASE INHIBITORS | GENZYME CORPORATION | 2021-06-10 | — | — | US | disclosed |
| US-20190322649-A1 | SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYLTRANSFERASE INHIBITORS | GENZYME CORPORATION | 2019-10-24 | — | — | US | disclosed |
| US-20170334888-A1 | SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYLTRANSFERASE INHIBITORS | GENZYME CORPORATION | 2017-11-23 | — | — | US | disclosed |
| US-9546161-B2 | Synthesis of UDP-glucose: N-acylsphingosine glucosyl transferase inhibitors | GENZYME CORPORATION (US) | 2017-01-17 | — | — | US | disclosed |
| US-20150148534-A1 | SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYL TRANSFERASE INHIBITORS | GENZYME CORPORATION | 2015-05-28 | — | — | US | disclosed |
| US-8779163-B2 | Synthesis of UDP-Glucose: N-acylsphingosine glucosyl transferase inhibitors | GENZYME CORPORATION (US) | 2014-07-15 | — | — | US | disclosed |
| EP-2266968-B1 | Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors | GENZYME CORP (US) | 2013-01-09 | — | — | EP | disclosed |
| US-20120296088-A1 | SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYL TRANSFERASE INHIBITORS | GENZYME CORPORATION | 2012-11-22 | — | — | US | disclosed |
| EP-2067775-B1 | A N-Acylsphingosine glucosyltransferase inhibitor | GENZYME CORP (US) | 2012-04-25 | — | — | EP | disclosed |
| EP-1409467-B1 | A N-ACYLSPHINGOSINE GLUCOSYLTRANSFERASE INHIBITOR | GENZYME CORP (US) | 2012-04-18 | — | — | EP | disclosed |
| US-7615573-B2 | Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-11-10 | — | — | US | disclosed |
| EP-2067775-A1 | Synthesis of UDP-glucose: N-Acylsphingosine glucosyltransferase inhibitors | GENZYME CORPORATION (US) | 2009-06-10 | — | — | EP | disclosed |
| US-20080058514-A1 | SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYLTRANSFERASE INHIBITORS | HIRTH BRADFORD H | 2008-03-06 | — | — | US | disclosed |
| US-7265228-B2 | Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors | GENZYME CORPORATION (US) | 2007-09-04 | — | — | US | disclosed |
| US-20070203223-A1 | Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2007-08-30 | — | — | US | disclosed |
| US-7196205-B2 | Synthesis of amino ceramide-like compounds; for treating Tay-Sachs, Gaucher's or Fabry's disease; amenable to large scale preparations | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2007-03-27 | — | — | US | disclosed |
| US-20050222244-A1 | Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors | GENZYME CORPORATION (US) | 2005-10-06 | — | — | US | disclosed |
| US-6855830-B2 | Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors | GENZYME CORPORATION (US) | 2005-02-15 | — | — | US | disclosed |
| US-20050009872-A1 | Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors | GENZYME CORPORATION (US) | 2005-01-13 | — | — | US | disclosed |
| US-20030050299-A1 | An intermediates for enantiomeric synthesis cermamide-like inhibitors; producing antilipemic agents | GENZYME CORPORATION | 2003-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120296088-A1 | SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYL TRANSFERASE INHIBITORS | UGCG, UGGT1, DPAGT1 | TP53 4869/4885MAOB 1986/4885MAOA 2052/4885 |
| US-20050222244-A1 | Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors | UGCG, UGGT1, DPAGT1 | TP53 4846/4885MAOB 2234/4885MAOA 2224/4885 |
| US-20210171507-A1 | SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYLTRANSFERASE INHIBITORS | UGCG, UGGT1, DPAGT1 | TP53 4846/4885MAOB 2234/4885MAOA 2224/4885 |
| US-20170334888-A1 | SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYLTRANSFERASE INHIBITORS | UGCG, UGGT1, DPAGT1 | TP53 4846/4885MAOB 2234/4885MAOA 2224/4885 |
| US-20150148534-A1 | SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYL TRANSFERASE INHIBITORS | UGCG, UGGT1, DPAGT1 | TP53 4869/4885MAOB 1986/4885MAOA 2052/4885 |
| US-20080058514-A1 | SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYLTRANSFERASE INHIBITORS | UGCG, UGGT1, DPAGT1 | TP53 4846/4885MAOB 2234/4885MAOA 2224/4885 |
| US-20190322649-A1 | SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYLTRANSFERASE INHIBITORS | UGCG, UGGT1, DPAGT1 | TP53 4846/4885MAOB 2234/4885MAOA 2224/4885 |
| US-20050009872-A1 | Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors | UGCG, UGGT1, DPAGT1 | TP53 4846/4885MAOB 2234/4885MAOA 2224/4885 |
| US-20070203223-A1 | Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors | UGCG, UGGT1, DPAGT1 | TP53 4846/4885MAOB 2234/4885MAOA 2224/4885 |
| US-20030050299-A1 | An intermediates for enantiomeric synthesis cermamide-like inhibitors; producing antilipemic agents | UGCG, UGGT1, LCLAT1 | TP53 4824/4885MAOB 2000/4885MAOA 1924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.