Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTP1 | P09211 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19795842 | 0.82 | ALDH1A1 (0.34) | TP53MEN1KMT2A | |
| SCHEMBL18011887 | 0.81 | MAPK1 (0.44) | L3MBTL1MAOBMAOAMEN1KMT2A | |
| SCHEMBL18011890 | 0.79 | MDM2 (0.38) | MEN1KMT2A | |
| SCHEMBL18012015 | 0.79 | STING1 (0.35) | MEN1KMT2A | |
| SCHEMBL19795849 | 0.78 | MAPK1 (0.41) | MAOBMEN1KMT2A | |
| SCHEMBL8444217 | 0.77 | TP53 (0.35) | EGFRTP53MAOBMAOANAAA | |
| SCHEMBL4205273 | 0.75 | IDH1 (0.36) | MAOBMAOAMEN1KMT2A | |
| SCHEMBL13375718 | 0.75 | IDH1 (0.36) | MAOBMAOAMEN1KMT2A | |
| SCHEMBL5552934 | 0.75 | IDH1 (0.36) | MAOBMAOAMEN1KMT2A | |
| SCHEMBL23484125 | 0.75 | NAAA (0.47) | TP53PRKDCMAOBMAOANAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170334888-A1 | SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYLTRANSFERASE INHIBITORS | GENZYME CORPORATION | 2017-11-23 | — | — | US | disclosed |
| US-9546161-B2 | Synthesis of UDP-glucose: N-acylsphingosine glucosyl transferase inhibitors | GENZYME CORPORATION (US) | 2017-01-17 | — | — | US | disclosed |
| US-20150148534-A1 | SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYL TRANSFERASE INHIBITORS | GENZYME CORPORATION | 2015-05-28 | — | — | US | disclosed |
| US-8779163-B2 | Synthesis of UDP-Glucose: N-acylsphingosine glucosyl transferase inhibitors | GENZYME CORPORATION (US) | 2014-07-15 | — | — | US | disclosed |
| US-20120296088-A1 | SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYL TRANSFERASE INHIBITORS | GENZYME CORPORATION | 2012-11-22 | — | — | US | disclosed |
| US-8138353-B2 | Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors | GENZYME CORPORATION (US) | 2012-03-20 | — | — | US | disclosed |
| US-20110003987-A1 | SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYLTRANSFERASE INHIBITORS | GENZYME CORPORATION | 2011-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120296088-A1 | SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYL TRANSFERASE INHIBITORS | UGCG, UGGT1, DPAGT1 | GSTP1 1221/4885EGFR 4806/4885TP53 4869/4885 |
| US-20170334888-A1 | SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYLTRANSFERASE INHIBITORS | UGCG, UGGT1, DPAGT1 | GSTP1 1355/4885EGFR 4740/4885TP53 4846/4885 |
| US-20110003987-A1 | SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYLTRANSFERASE INHIBITORS | UGCG, UGGT1, DPAGT1 | GSTP1 1355/4885EGFR 4740/4885TP53 4846/4885 |
| US-20150148534-A1 | SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYL TRANSFERASE INHIBITORS | UGCG, UGGT1, DPAGT1 | GSTP1 1221/4885EGFR 4806/4885TP53 4869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.