Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7856497 | 0.81 | MAPT (0.50) | LMNAITGB3ITGA2BSMN1; SMN2KCNK3 | |
| SCHEMBL8500073 | 0.79 | MAPT (0.49) | LMNAITGB3ITGA2BSMN1; SMN2ITGAV | |
| SCHEMBL7379804 | 0.78 | ITGB3 (0.55) | LMNANPC1RAB9AITGB3ITGA2B | |
| SCHEMBL8500653 | 0.77 | ITGB3 (0.60) | LMNANPC1RAB9AITGB3ITGA2B | |
| SCHEMBL7378623 | 0.76 | SMN1; SMN2 (0.58) | NPC1RAB9AITGB3ITGA2BSMN1; SMN2 | |
| SCHEMBL7380108 | 0.76 | LMNA (0.46) | LMNANPC1RAB9AITGB3ITGA2B | |
| SCHEMBL7377637 | 0.75 | MAPT (0.55) | LMNAITGB3ITGA2BSMN1; SMN2BCHE | |
| SCHEMBL7339409 | 0.73 | ITGB3 (0.41) | ITGB3ITGA2BGAASMN1; SMN2KCNK3 | |
| SCHEMBL7377063 | 0.73 | ITGB3 (0.47) | LMNARAB9AITGB3ITGA2BSMN1; SMN2 | |
| SCHEMBL7380122 | 0.73 | ITGB3 (0.56) | NPC1ITGB3ITGA2BSMN1; SMN2KCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891325-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-01-20 | — | — | EP | claimed |
| WO-1997036859-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |