Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.51 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7349701 | 0.96 | MAPT (0.58) | MAPTKDM4EALDH1A1POLBPKM | |
| SCHEMBL7356928 | 0.91 | MAPT (0.54) | MAPTKDM4EALDH1A1POLBPKM | |
| SCHEMBL7389078 | 0.86 | KMT2A (0.47) | MAPTKDM4EALDH1A1POLBPKM | |
| SCHEMBL8147273 | 0.84 | MAPT (0.65) | MAPTKDM4EALDH1A1POLBPKM | |
| SCHEMBL14364287 | 0.82 | MAPT (0.60) | MAPTKDM4EALDH1A1POLBPKM | |
| SCHEMBL6233037 | 0.82 | ALDH1A1 (0.67) | MAPTKDM4EALDH1A1POLBPKM | |
| SCHEMBL7361776 | 0.82 | MAPT (0.50) | MAPTKDM4EALDH1A1POLBPKM | |
| SCHEMBL7359455 | 0.82 | MAPT (0.48) | MAPTKDM4EALDH1A1POLBPKM | |
| SCHEMBL8107611 | 0.81 | MAPT (0.60) | MAPTKDM4EALDH1A1POLBPKM | |
| SCHEMBL29306545 | 0.81 | HCAR3 (0.67) | MAPTKDM4EALDH1A1POLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288065-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PARKINSON*S AND ALZHEIMER*S DISEASE | SCHERING AKTIENGESEELLSCHAFT (DE) | 2001-09-11 | — | — | US | disclosed |
| US-6057304-A | Quinoxaline-phosphonic acid derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |
| CN-1038840-C | para-dinitrogen naphthalene derivative, its preparation method and its medical use | SCHERING AG (DE) | 1998-06-24 | — | — | CN | disclosed |
| EP-0565683-A1 | QUINOXALINE DERIVATES WITH AFFINITY FOR QUISQUALATE-RECEPTORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1993-10-20 | — | — | EP | disclosed |
| CN-1072929-A | Para-dinitronaphthalene derivative, preparation method and medical application thereof | SCHERING AG (DE) | 1993-06-09 | — | — | CN | disclosed |
| WO-1993008173-A1 | QUINOXALINE DERIVATES WITH AFFINITY FOR QUISQUALATE-RECEPTORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1993-04-29 | — | — | WO | disclosed |