Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7356928 | 0.85 | MAPT (0.54) | MAPTPOLBPKMKDM4EALDH1A1 | |
| SCHEMBL7350263 | 0.85 | ALDH1A1 (0.52) | MAPTPOLBPKMKDM4EALDH1A1 | |
| SCHEMBL7349273 | 0.84 | KCNMA1 (0.50) | MAPTPOLBPKMALDH1A1MAPK1 | |
| SCHEMBL7355699 | 0.84 | KAT2B (0.58) | MAPTPOLBPKMALDH1A1MAPK1 | |
| SCHEMBL7358011 | 0.84 | MAPT (0.52) | MAPTKDM4EALDH1A1MAPK1MEN1 | |
| SCHEMBL7361382 | 0.84 | PKM (0.47) | MAPTPKMKDM4EALDH1A1MAPK1 | |
| SCHEMBL7351297 | 0.84 | ALDH1A1 (0.57) | MAPTPOLBPKMALDH1A1MEN1 | |
| SCHEMBL7349701 | 0.83 | MAPT (0.58) | MAPTPOLBPKMKDM4EALDH1A1 | |
| SCHEMBL7380491 | 0.82 | MAPT (0.57) | MAPTPOLBPKMKDM4EALDH1A1 | |
| SCHEMBL8107611 | 0.80 | MAPT (0.60) | MAPTPOLBPKMKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288065-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PARKINSON*S AND ALZHEIMER*S DISEASE | SCHERING AKTIENGESEELLSCHAFT (DE) | 2001-09-11 | — | — | US | disclosed |
| US-6057304-A | Quinoxaline-phosphonic acid derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |
| CN-1038840-C | para-dinitrogen naphthalene derivative, its preparation method and its medical use | SCHERING AG (DE) | 1998-06-24 | — | — | CN | disclosed |
| CN-1072929-A | Para-dinitronaphthalene derivative, preparation method and medical application thereof | SCHERING AG (DE) | 1993-06-09 | — | — | CN | disclosed |