Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.62 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.57 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.57 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.57 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.57 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7382516 | 0.90 | ADORA3 (0.50) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7378260 | 0.86 | TSHR (0.52) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL6951320 | 0.86 | ADORA3 (0.76) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7384736 | 0.85 | ADORA3 (0.46) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL11183629 | 0.84 | NR1I2 (0.47) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7372591 | 0.84 | NR1I2 (0.53) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7376036 | 0.84 | ABCB11 (0.59) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7382219 | 0.83 | MAPT (0.68) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7385666 | 0.83 | ADRA2A (0.48) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL11024936 | 0.83 | ADORA3 (0.55) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4525478-A | Certain 4-aryl-1,4-dihydro-3,5-pyridinedicarboxylates having vasodilating and anti-hypertensive properties | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-06-25 | — | — | US | disclosed |
| US-4370334-A | VASODILATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-01-25 | — | — | US | disclosed |
| US-4338322-A | 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1982-07-06 | — | — | US | disclosed |
| US-4284634-A | HYPOTENSIVE VASODILATORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-08-18 | — | — | US | disclosed |