Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 5/20 | 0.58 |
| ▸ | GABRD | O14764 | 5/20 | 0.58 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.58 |
| ▸ | GABRB1 | P18505 | 5/20 | 0.58 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.58 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.58 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.58 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.58 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.58 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.58 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.58 |
| ▸ | GABRE | P78334 | 5/20 | 0.58 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.58 |
| ▸ | GABRG1 | Q8N1C3 | 5/20 | 0.58 |
| ▸ | GABRG3 | Q99928 | 5/20 | 0.58 |
| ▸ | GABRQ | Q9UN88 | 5/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | TERT | O14746 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7378162 | 0.83 | CYP3A4 (0.76) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7374638 | 0.79 | CYP1A1 (0.65) | TERTKDM4EALDH1A1TP53CYP3A4 | |
| SCHEMBL7373845 | 0.78 | MAPT (0.48) | CA12CA9TERTKDM4EALDH1A1 | |
| SCHEMBL7376625 | 0.78 | ALDH1A1 (0.58) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6617221 | 0.77 | TERT (0.64) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7377806 | 0.76 | MAPT (0.54) | CA12CA9KDM4EALDH1A1CYP3A4 | |
| SCHEMBL7369647 | 0.76 | TERT (0.74) | TERTKDM4EALDH1A1TP53CYP3A4 | |
| SCHEMBL12835500 | 0.75 | GABRP (0.56) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL16894631 | 0.75 | GABRP (0.81) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6613764 | 0.74 | TERT (0.71) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115718-A1 | HYDROXYFLAVONE DERIVATIVES AS TAU PROTEIN KINASE 1 INHIBITORS | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000017184-A1 | HYDROXYFLAVONE DERIVATIVES AS TAU PROTEIN KINASE 1 INHIBITORS | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-03-30 | — | — | WO | disclosed |