Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6396188 | 0.76 | FLT3 (0.54) | FLT3MAP2K1DRD2DRD3KDM4E | |
| SCHEMBL1934934 | 0.69 | L3MBTL1 (0.39) | ALDH1A1 | |
| SCHEMBL771326 | 0.67 | KDR (0.43) | KDM4EALDH1A1GAAIDO1HRH4 | |
| SCHEMBL6808774 | 0.67 | KMT2A (0.41) | AHRALDH1A1 | |
| SCHEMBL9688648 | 0.66 | HRH4 (0.49) | FLT3MAP2K1KDM4EALDH1A1HTR2C | |
| SCHEMBL13394197 | 0.66 | L3MBTL1 (0.41) | ALDH1A1 | |
| SCHEMBL17242701 | 0.65 | LMNA (0.57) | KDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL31593956 | 0.65 | PIK3CD (0.36) | — | |
| SCHEMBL21039172 | 0.65 | ALDH1A1 (0.36) | ALDH1A1 | |
| SCHEMBL12045263 | 0.65 | KDM4E (0.46) | AHRFLT3DRD2DRD3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420086-B1 | Pyrimidoindole derivatives and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-12-13 | — | — | EP | disclosed |
| US-5256780-A | Serotonin antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-10-26 | — | — | US | disclosed |
| US-5180728-A | Antagonists of 5-hydroxytryptamine | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1993-01-19 | — | — | US | disclosed |
| EP-0420086-A2 | Pyrimidoindole derivatives and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-04-03 | — | — | EP | disclosed |