Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 3/20 | 0.51 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.51 |
| ▸ | ITGAL | P20701 | 3/20 | 0.51 |
| ▸ | REN | P00797 | 5/20 | 0.50 |
| ▸ | HTR1D | P28221 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | HTR1E | P28566 | 2/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | MME | P08473 | 1/20 | 0.47 |
| ▸ | ECE1 | P42892 | 1/20 | 0.47 |
| ▸ | NLN | Q9BYT8 | 2/20 | 0.46 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7386111 | 0.88 | REN (0.48) | ITGB2ICAM1ITGALRENHTR1D | |
| SCHEMBL9875941 | 0.85 | MME (0.59) | RENHTR1DHTR2CHTR1EHTR2B | |
| SCHEMBL13912236 | 0.81 | HTR1D (0.49) | ITGB2ICAM1ITGALHTR1DHTR2C | |
| SCHEMBL7380910 | 0.80 | KMT2A (0.45) | KMT2A | |
| SCHEMBL10422014 | 0.78 | REN (0.53) | RENNLNPDCD1CD274 | |
| SCHEMBL11158707 | 0.77 | ITGB2 (0.58) | ITGB2ICAM1ITGALHTR1DHTR2C | |
| SCHEMBL27342814 | 0.77 | REN (0.56) | ITGB2ICAM1ITGALRENHTR1D | |
| Triletide SCHEMBL29387766 | 0.76 | REN (0.68) | RENHTR1DHTR2CHTR1EHTR2B | |
| Triletide SCHEMBL29403076 | 0.76 | REN (0.68) | RENHTR1DHTR2CHTR1EHTR2B | |
| Bromide SCHEMBL27422846 | 0.76 | REN (0.58) | RENMMEECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4870183-A | RENIN INHIBITORS, HYPOTENSIVES | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-26 | — | — | US | disclosed |
| EP-0252727-A1 | Novel amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1988-01-13 | — | — | EP | disclosed |