Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 12/20 | 0.71 |
| ▸ | FNTA | P49354 | 2/20 | 0.43 |
| ▸ | FNTB | P49356 | 1/20 | 0.43 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.42 |
| ▸ | NLN | Q9BYT8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10722653 | 0.92 | REN (0.70) | RENFNTAFNTBPGGT1B | |
| SCHEMBL7283924 | 0.87 | REN (0.63) | RENFNTAFNTBPGGT1BNLN | |
| SCHEMBL10756718 | 0.85 | REN (0.53) | REN | |
| SCHEMBL7333736 | 0.85 | REN (0.53) | REN | |
| SCHEMBL10579060 | 0.84 | REN (0.59) | REN | |
| SCHEMBL10422493 | 0.82 | REN (0.64) | REN | |
| SCHEMBL6013385 | 0.81 | REN (0.67) | REN | |
| SCHEMBL10522368 | 0.79 | REN (0.54) | RENFNTAPGGT1B | |
| SCHEMBL10520328 | 0.78 | REN (0.54) | RENFNTAFNTBPGGT1BNLN | |
| SCHEMBL10572007 | 0.78 | REN (0.59) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4870183-A | RENIN INHIBITORS, HYPOTENSIVES | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-26 | — | — | US | disclosed |
| US-4711958-A | HYPOTENSIVE AGENTS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1987-12-08 | — | — | US | disclosed |
| EP-0244083-A2 | Amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1987-11-04 | — | — | EP | disclosed |
| US-4656269-A | RENIN INHIBITORY EFFECT WHEN ADMINISTERING ORALLY; HYPOTENSIVE AGENTS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1987-04-07 | — | — | US | disclosed |
| EP-0200406-A2 | Novel amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-11-05 | — | — | EP | disclosed |