Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 8/20 | 0.54 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.47 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.47 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.47 |
| ▸ | FNTA | P49354 | 2/20 | 0.45 |
| ▸ | MME | P08473 | 1/20 | 0.45 |
| ▸ | ECE1 | P42892 | 1/20 | 0.45 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.45 |
| ▸ | FNTB | P49356 | 1/20 | 0.45 |
| ▸ | NLN | Q9BYT8 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10522368 | 0.86 | REN (0.54) | RENFNTAPGGT1B | |
| SCHEMBL10520319 | 0.84 | HRH4 (0.44) | RENERAP2ERAP1 | |
| SCHEMBL10422014 | 0.82 | REN (0.53) | RENFNTAPGGT1BNLN | |
| SCHEMBL9875941 | 0.79 | MME (0.59) | RENMMEECE1 | |
| SCHEMBL10872035 | 0.78 | REN (0.55) | RENFNTAMMEECE1PGGT1B | |
| SCHEMBL7381945 | 0.78 | REN (0.71) | RENFNTAPGGT1BFNTBNLN | |
| SCHEMBL29486802 | 0.76 | REN (0.64) | REN | |
| SCHEMBL10825069 | 0.76 | REN (0.64) | REN | |
| SCHEMBL25054175 | 0.76 | REN (0.56) | RENERAP2ERAP1LNPEP | |
| SCHEMBL7380911 | 0.76 | ITGB2 (0.51) | RENMMEECE1NLN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |