Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | ELANE | P08246 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4766674 | 0.80 | PIM1 (0.55) | PIM1KMT2AKDM4EALDH1A1CA12 | |
| SCHEMBL9319353 | 0.76 | BCL2L1 (0.46) | PIM1KMT2AKDM4EPOLBCA12 | |
| SCHEMBL5560761 | 0.74 | KDM4E (0.64) | KMT2ASMN1; SMN2KDM4EPOLBALDH1A1 | |
| SCHEMBL11845147 | 0.74 | CA12 (0.55) | PIM1KMT2ASMN1; SMN2KDM4EPOLB | |
| SCHEMBL10712556 | 0.73 | HPGD (0.50) | PIM1KDM4EPOLBALDH1A1CA12 | |
| SCHEMBL7470487 | 0.71 | PIM1 (0.61) | PIM1KMT2ASMN1; SMN2KDM4EPOLB | |
| SCHEMBL11745931 | 0.71 | PIM1 (0.57) | PIM1KMT2ASMN1; SMN2KDM4EPOLB | |
| SCHEMBL31064944 | 0.70 | ALDH1A1 (0.56) | PIM1SMN1; SMN2KDM4EPOLBALDH1A1 | |
| SCHEMBL20563607 | 0.70 | PIM1 (0.56) | PIM1KDM4EALDH1A1LMNATP53 | |
| SCHEMBL175987 | 0.69 | ALDH1A1 (0.59) | PIM1KMT2ASMN1; SMN2KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6486155-B1 | Method of inhibiting neoplastic cells with isoquinoline derivatives | CELL PATHWAYS INC | 2002-11-26 | — | — | US | disclosed |
| WO-1998038168-A1 | ISOQUINOLINONE DERIVATIVES, PROCESS FOR PREPARING THE SAME, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | TANABE SEIYAKU CO., LTD. (JP) | 1998-09-03 | — | — | WO | disclosed |
| US-5371220-A | Bicyclo-heterocyclic intermediates for cephalosporin compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-12-06 | — | — | US | disclosed |
| US-5232918-A | Bactericides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-03 | — | — | US | disclosed |
| US-5019570-A | Antibioics | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-05-28 | — | — | US | disclosed |