SCHEMBL738277

SCHEMBL738277

N[C@H]1CC[C@H](N(Cc2ccccc2)C(=O)O)CC1

nearest known ligand 0.54

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MC4R P32245 3/20 0.54
MC3R P41968 3/20 0.54
MC5R P33032 2/20 0.54
AGER Q15109 3/20 0.49
MTNR1A P48039 1/20 0.49
CHRM2 P08172 1/20 0.49
CHRM3 P20309 1/20 0.49
OPRM1 P35372 6/20 0.48
CTSD P07339 1/20 0.48
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
SLC6A9 P48067 2/20 0.45
KCNH2 Q12809 2/20 0.45
SLC6A5 Q9Y345 2/20 0.45
KDM1A O60341 1/20 0.43
DPP4 P27487 1/20 0.43
DPP9 Q86TI2 1/20 0.43
DPP7 Q9UHL4 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL77425 1.00 MC4R (0.54) MC4RMC3RMC5RAGERMTNR1A
SCHEMBL3370759 0.91 AGER (0.55) AGERMTNR1ACHRM2CHRM3OPRM1
SCHEMBL1700010 0.90 MC4R (0.49) MC4RMC3RMC5RAGERMTNR1A
SCHEMBL17506917 0.90 MC4R (0.49) MC4RMC3RMC5RAGERMTNR1A
SCHEMBL736913 0.85 AGER (0.50) MC4RMC3RMC5RAGERMTNR1A
SCHEMBL736914 0.85 AGER (0.50) MC4RMC3RMC5RAGERMTNR1A
SCHEMBL13275447 0.84 OPRM1 (0.51) AGERMTNR1ACHRM2CHRM3OPRM1
SCHEMBL2400009 0.84 OPRM1 (0.51) AGERMTNR1ACHRM2CHRM3OPRM1
SCHEMBL862071 0.84 AGER (0.47) MC4RMC3RMC5RAGERMTNR1A
SCHEMBL2400012 0.84 OPRM1 (0.51) AGERMTNR1ACHRM2CHRM3OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4745129-A2 COMPOUND HAVING CYCLIC STRUCTURE Daiichi Sankyo Company, Limited (JP) 2026-05-20 EP disclosed
EP-3682881-B1 COMPOUND HAVING CYCLIC STRUCTURE DAIICHI SANKYO CO LTD (JP) 2026-04-01 EP disclosed
US-12297187-B2 Compound having cyclic structure DAIICHI SANKYO COMPANY, LIMITED (JP) 2025-05-13 US disclosed
US-20230331700-A1 COMPOUND HAVING CYCLIC STRUCTURE DAIICHI SANKYO COMPANY, LIMITED (JP) 2023-10-19 US disclosed
US-11512067-B2 Compound having cyclic structure DAIICHI SANKYO COMPANY, LIMITED (JP) 2022-11-29 US disclosed
US-20200347030-A1 COMPOUND HAVING CYCLIC STRUCTURE DAIICHI SANKYO COMPANY, LIMITED (JP) 2020-11-05 US disclosed
EP-3682881-A1 COMPOUND HAVING CYCLIC STRUCTURE DAIICHI SANKYO COMPANY, LIMITED (JP) 2020-07-22 EP disclosed
US-8138339-B2 Inhibitors of protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2012-03-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12297187-B2 Compound having cyclic structure H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, ECE1, IL1B MC4R 1772/4885MC3R 1041/4885MC5R 842/4885
US-20200347030-A1 COMPOUND HAVING CYCLIC STRUCTURE H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, ECE1, IL1B MC4R 1772/4885MC3R 1041/4885MC5R 842/4885
US-11512067-B2 Compound having cyclic structure H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, ECE1, IL1B MC4R 1772/4885MC3R 1041/4885MC5R 842/4885
US-20230331700-A1 COMPOUND HAVING CYCLIC STRUCTURE H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, ECE1, IL1B MC4R 1772/4885MC3R 1041/4885MC5R 842/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.