Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1491181 | 0.69 | KDM4E (0.33) | HTR2CHTR2BKDM4EMEN1ALDH1A1 | |
| SCHEMBL1661412 | 0.69 | BRD4 (0.34) | HTR2CHTR2BKDM4EMEN1ALDH1A1 | |
| SCHEMBL22115886 | 0.69 | KDM4E (0.33) | HTR2CHTR2BKDM4EMEN1ALDH1A1 | |
| SCHEMBL3235007 | 0.69 | KDM4E (0.33) | HTR2CHTR2BKDM4EMEN1ALDH1A1 | |
| SCHEMBL3342528 | 0.69 | KDM4E (0.37) | HTR2CHTR2BKDM4EMEN1ALDH1A1 | |
| SCHEMBL5494922 | 0.69 | KDM4E (0.33) | HTR2CHTR2BKDM4EMEN1ALDH1A1 | |
| SCHEMBL3783557 | 0.68 | P2RX4 (0.33) | HTR2CHTR2BKDM4EMEN1ALDH1A1 | |
| SCHEMBL3098531 | 0.67 | MEN1 (0.34) | MEN1KMT2A | |
| SCHEMBL5999468 | 0.67 | LMNA (0.42) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL15201897 | 0.67 | HTR2C (0.32) | HTR2CHTR2BKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 130 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110218217-A | Benzoxazine -2- ketone and benzimidazoles compound and its preparation method and application | 湖南科技大学 | 2019-09-10 | — | — | CN | claimed |
| CN-105017238-A | Method for chiral spirophosphonate catalyzed synthesis of optically active 2H-1,4-benzoxazine-2-one derivative | UNIV ZHEJIANG | 2015-11-04 | — | — | CN | claimed |
| CN-101450933-A | Method for preparing polysubstituted 3,4-dihydro-3-methyl-2H-1,4-benzoxazine-2-one | UNIV EAST CHINA SCIENCE & TECH (CN) | 2009-06-10 | — | — | CN | claimed |
| CN-1953967-A | Purification of progesterone receptor modulators | WYETH CORP (US) | 2007-04-25 | — | — | CN | claimed |
| CN-1191242-C | Different crystalyzed (-)-6-chloro-4-cyclopropyl ethinyl-4-trifluoride-1,4-dihydro-2H-3,1-benzoxazine-2-ketone | MERCK & CO INC (US) | 2005-03-02 | — | — | CN | claimed |
| CN-1385425-A | Different crystalyzed (-)-6-chloro-4-cyclopropyl ethinyl-4-trifluoride-1,4-dihydro-2H-3,1-benzoxazine-2-ketone | MERCK & CO INC (US) | 2002-12-18 | — | — | CN | claimed |
| CN-1073992-C | Efficient synthesis of 1,4-dihydro-2H-3, 1-benzoxazine-2-one | MERCK & CO INC (US) | 2001-10-31 | — | — | CN | claimed |
| CN-1073991-C | Crystallization process of reverse transcriptase inhibitors using anti-solvents | MERCK & CO INC (US) | 2001-10-31 | — | — | CN | claimed |
| CN-1051767-C | Benzoxazinones as HIV Reverse Transcriptase Inhibitors | MERCK & CO INC (US) | 2000-04-26 | — | — | CN | claimed |
| CN-1246852-A | Efficient synthesis of 1,4-dihydro-2H-3, 1-benzoxazine-2-one | MERCK & CO INC (US) | 2000-03-08 | — | — | CN | claimed |
| CN-1246113-A | Crystallization process of reverse transcriptase inhibitors using anti-solvents | MERCK & CO INC (US) | 2000-03-01 | — | — | CN | claimed |
| CN-1090277-A | Benzoxazinones as HIV Reverse Transcriptase Inhibitors | MERCK & CO INC (US) | 1994-08-03 | — | — | CN | claimed |
| CN-110204506-B | CO 2 Synthesis of 1,4-dihydro-2H-3,1-benzoxazine-2-one derivative as C1 source | 常州大学 | 2022-10-28 | — | — | CN | disclosed |
| CN-109593096-B | Tricyclic heterocycles as BET protein inhibitors | 因赛特公司 | 2022-01-14 | — | — | CN | disclosed |
| CN-110382470-A | The preparation method of efavirenz | 纳尔逊·曼德拉都市大学 | 2019-10-25 | — | — | CN | disclosed |
| CN-110218217-A | Benzoxazine -2- ketone and benzimidazoles compound and its preparation method and application | 湖南科技大学 | 2019-09-10 | — | — | CN | disclosed |
| CN-1140174-A | Piperidine derivatives, process for preparation thereof and application thereof in therapeutics | SYNTHELABO (FR) | 1997-01-15 | — | — | CN | disclosed |
| CN-1109471-A | Derivative of imidazol-4yl-piperidine, preparation of same and application of same in treatment | SYNTHELABO (FR) | 1995-10-04 | — | — | CN | disclosed |
| CN-1049770-A | Weeding glutaramic acid and its derivative | ROHM & HAAS (US) | 1991-03-13 | — | — | CN | disclosed |
| CN-1049846-A | Glutarimide with weeding activity | ROHM & HAAS (US) | 1991-03-13 | — | — | CN | disclosed |